2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-153577
    WT-TTR inhibitor 1 23983-05-3 98.03%
    WT-TTR inhibitor 1 (Compound 21) is a wild-type Transthyretin (WT-TTR) inhibitor with 29.05% inhibition at 100 μM.
    WT-TTR inhibitor 1
  • HY-153822
    JG-23 2640819-75-4 99.64%
    JG-23 is a 4-chloro modified analog with ability to promote t-tau degradation. JG-23 exhibits good metabolic stability with a long T1/2 value (36 min) in mouse liver microsome assays.
    JG-23
  • HY-154436
    Anticonvulsant agent 2 75220-84-7 98%
    Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity.
    Anticonvulsant agent 2
  • HY-15498A
    Rimegepant sulfate hydrate 1374024-48-2 98%
    Rimegepant (sulfate hydrate) is an orally active, selective and competitive calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 0.027 nM. Rimegepant (sulfate hydrate) can be used in migraine related research.
    Rimegepant sulfate hydrate
  • HY-155367
    mAChR antagonist 1 101491-79-6 99.59%
    mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively.
    mAChR antagonist 1
  • HY-155369
    BChE-IN-21 98%
    BChE-IN-21 is a potent BChE inhibitor with an IC50 of 0.14 ± 0.02 μM. BChE-IN-21 has the potential for alzheimer's disease research.
    BChE-IN-21
  • HY-156023
    SIRT1 activator 2 863589-52-0 99.28%
    SIRT1 activator 2 (compound 212) is a SIRT1 activator with an ED50 of < 5 μM. SIRT1 activator 2 can be used for increasing the lifespan of a cell.
    SIRT1 activator 2
  • HY-156027
    SIRT6-IN-3 3023471-40-8 98.19%
    SIRT6-IN-3 (compound 8a) is a selective inhibitor of SIRT6 (IC50=7.49 μM). SIRT6-IN-3 inhibits pancreatic ductal adenocarcinoma (PDAC) cells proliferation and induces apoptosis. SIRT6-IN-3 increases the sensitivity of cancer cells to gemcitabine (HY-17026) via blocking the DNA damage repair pathway. SIRT6-IN-3 is used in pancreatic cancer research.
    SIRT6-IN-3
  • HY-156532
    5-HT2C agonist-3 2104810-18-4 99.86%
    5-HT2C agonist-3 ((+)-19) is a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM). 5-HT2C agonist-3 has antipsychotic drug-like activity. 5-HT2C agonist-3 blocks Amphetamine-induced hyperactivity.
    5-HT2C agonist-3
  • HY-156666
    Casein kinase 1δ-IN-8 851396-73-1 98.0%
    Casein kinase 1δ-IN-8 (compound 494) is an inhibitor of Casein kinase 1δ, Casein kinase 1δ-IN-8 can be used in the treatment of neurodegenerative disorders such as Alzheimer's disease[1].
    Casein kinase 1δ-IN-8
  • HY-156842
    MCAAD-3 1625629-51-7
    MCAAD-3 is a near-infrared Aβ imaging probe with blood-brain barrier penetrability. MCAAD-3 has a strong affinity for Aβ polymers (Ki >106 nM) and can label Aβ plaques in the brains of transgenic mice.
    MCAAD-3
  • HY-15720B
    Glycyl H-1152 hydrochloride 913844-45-8 99.9%
    Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC50s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride.
    Glycyl H-1152 hydrochloride
  • HY-157343
    GD3 Ganglioside 62010-37-1 98%
    GD3 Ganglioside is a prominent ganglioside of human melanoma. GD3 Ganglioside is an inducer of mitochondrial permeability. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. GD3 ganglioside is rapidly synthesized from accumulated ceramide after the clustering of death-inducing receptors and triggers apoptosis.
    GD3 Ganglioside
  • HY-157549
    Brivoligide 1803075-42-4 98%
    Brivoligide (AYX1) is a double-stranded, unprotected, 23 base-pair oligonucleotide. Brivoligide can reduce acute post-surgical pain. Brivoligide mimics the DNA sequence normally bound by EGR1 on chromosomes.
    Brivoligide
  • HY-158204
    CNB-001 1019110-87-2 98%
    CNB-001 is a potent and orally active 5-lipoxygenase (5-LOX) inhibitor. CNB-001 can decreases 5-LOX expression and increase proteasome activity. CNB-001 can inhibit accumulation of soluble Amyloid-β and ubiquitinated aggregated proteins. CNB-001 can inhibit apoptosis, ROS production and stabilize mitochondrial membrane potential. CNB-001 can reduce insulin resistance and increase glucose uptake. CNB-001 also exhibits anti-ischemic, anti-inflammatory effects. CNB-001 can be used for the researches of inflammation, neurological and metabolic disease, such as Alzheimer's disease, stroke and diabetes.
    CNB-001
  • HY-158756
    3-EEC hydrochloride 2446466-61-9 98%
    3-EEC hydrochloride is the hydrochloride of 3-EEC. 3-EEC belongs to the class of central nervous system stimulants. 3-EEC can be used for the study of neurological disease.
    3-EEC hydrochloride
  • HY-159109
    HDAC6-IN-46 3038789-39-5 98.51%
    HDAC6-IN-46 (compound 12) is a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 value of 6.2 nM. HDAC6-IN-46 can be used in Alzheimer's disease research.
    HDAC6-IN-46
  • HY-159836
    Nivegacetor 2443487-67-8 98%
    Nivegacetor is a potent γ-secretase modulator.
    Nivegacetor
  • HY-15997C
    (±)-U-50488 hydrate hydrochloride 99.76%
    (±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrate hydrochloride is a selective κ opioid receptor (KOR) agonist.
    (±)-U-50488 hydrate hydrochloride
  • HY-160115
    TDP-43 degrader-1 2902692-25-3
    TDP-43 degrader-1 (Compound example 7) is a TDP-43 degrader. TDP-43 degrader-1 reduces the aggregation of TDP-43-positive HuR stress granules in cells and promotes the relocalization of abnormally distributed TDP-43 in the cytoplasm to the nucleus. TDP-43 degrader-1 can be used in the study of amyotrophic lateral sclerosis and Alzheimer's disease.
    TDP-43 degrader-1
Cat. No. Product Name / Synonyms Application Reactivity